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          Be Agilent Sure in Your Analysis of Host Cell Protein (HCP) Impurities

          Be Agilent Sure in Your Analysis of Host Cell Protein (HCP) Impurities

          To find reliable answers, you need techniques and technologies that give you speed without sacrificing data quality or spectral resolution. Count on Agilent innovations to streamline your workflow and enable accurate, reproducible results.

          Bacterial and mammalian cells are commonly used as host systems for producing human therapeutic proteins. Host cell proteins can pose a safety concern if administered along with the therapeutic compound. Therefore, removal is critical during the purification process.

          Click each icon to learn how Agilent can help at every step of your HCP analysis workflow.

          Sample prep

          Separation

          Columns

          Detection

          Analysis

          Service

          The Agilent AssayMAP Bravo platform automates complex sample preparation for HCP analysis, including enzymatic digestion and peptide fractionation. Its robotic precision improves reproducibility across users and labs. What’s more, it allows users to scale experiments up and down from a few samples to hundreds. Other advantages include:

          • The ability to process 8—96 samples in parallel
          • Precise flow control across the cartridge bed
          • Quantitative binding and elution
          • High-efficiency washing
          • Small elution volumes

          Achieve superior outcomes with the high-performance Agilent 1290 Infinity II LC system, and increase peak capacity for challenging separations with 2D-LC.

          Agilent’s new AdvanceBio Peptide Plus column provides the speed, sensitivity, and efficiency you need to quickly confirm and identify target proteins and peptides.

          The 6545XT AdvanceBio LC/Q-TOF pushes your protein analysis to new levels of performance and reproducibility. Iterative MS/MS allows you to identify low abundant host cell proteins in the presence of high concentration of drug product.

          Advanced data mining and processing tools in the Agilent MassHunter Software suite and protein metrics software help you quickly identify and quantify HCPs.

          You can trust Agilent CrossLab service experts to deliver valuable insights and keep your instruments running at top performance. Our industry-leading services—tailored to meet your needs—include technology refresh, application consulting, repairs, preventive maintenance, compliance verification, and education. Ask us how we can support your laboratory today.

          Everything you need to streamline HCP analysis

          Looking for detailed information on new techniques or innovations? Download application notes and other resources to help you achieve accurate results, every time.

          Learn more

          Featured webinar

          Going Deep with Host Cell Proteins—Rapid Low-level Identification and Quantitation

          Learn how to optimize your HCP workflow, and why iterative MS/MS can help you see lower-level peptides and PTMs. We’ll also explore how to perform targeted, sub-ppm HCP quantitation.

          Register now

          Featured resources for ensuring safety and efficacy

          Application note

          Host Cell Protein Analysis Using Agilent AssayMAP Bravo and 6545XT AdvanceBio LC/Q-TOF

          Read how we:

          • Achieved broad dynamic range and excellent reproducibility
          • Identified spiked-in proteins at single digit ppm levels with high confidence
          • Enabled fast, simple protein identification and semiquantification

          Read now

          On-demand webinar

          Register now

          Make your biopharma workflow more productive

          Designed for multiple biopharma workflows: Agilent 6545XT AdvanceBio LC/Q-TOF system

          Look closer

          Analyze highly complex biotherapeutic molecules: Agilent AdvanceBio columns

          Measure what matters

          Produce answers… not just data: Biologics and small molecule analysis

          Explore now

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          For Research Use Only. Not for use in diagnostic procedures.

          To stay up to date on best practices for biotherapeutic drug
          development and discovery, submit this form.

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